Conjugated Polymer Nanoparticles for Label-Free and Bioconjugate-Recognized DNA Sensing in Serum

Conjugated Polymer Nanoparticles for Label‐Free and Bioconjugate‐Recognized DNA Sensing in Serum

Hybridbio/-synthetic sensory conjugated polymer nanoparticles (CPNs) are developed for selective label-free detection of target ssDNA in serum. Carboxylic acid-functionalized anionic polyfluorene nanoparticles are rationally designed as signal amplifying unit to bioconjugate with amine functionalized single stranded oligonucleotides as a receptor. The covalent DNA coating can significantly impro...

Conjugated Polymer Nanoparticles in Bio- Sensing and Bio-Imaging

Conjugated Polymer Nanoparticles for Bioimaging

During the last decade, conjugated polymers have emerged as an interesting class of fluorescence imaging probes since they generally show high fluorescence brightness, high photostability, fast emission rates, non-blinking behavior and low cytotoxicity. The main concern related to most conjugated polymers is their lack of hydrophilicity and thereby poor bio-availability. This can, however, be o...

Photoluminescent polymer nanoparticles for label-free cellular imaging.

Novel polymer based photoluminescent nanoparticles were fabricated by ultra-sound induced emulsion polymerization and applied to bioimaging of human breast cancer SK-BR-3 cells after ethylenediamine treatment and conjugation with anti-ErbB2 antibody.

Conjugated polymer nanoparticles.

Conjugated polymer nanoparticles are highly versatile nano-structured materials that can potentially find applications in various areas such as optoelectronics, photonics, bio-imaging, bio-sensing and nanomedicine. Their straightforward synthesis in desired sizes and properties, biocompatibility and non-toxicity make these materials highly attractive for the aforementioned applications. This fe...